Granules

Granules

Pharmaceutical granules

Purpose of Granulation

Granules are produced from fine powder particles through granulation or agglomeration processes. The primary objective of granulation is to improve flow behavior, reduce segregation and enhance handling properties compared to non-granulated powders. As a result, granules exhibit superior processability in pharmaceutical manufacturing.

Role in Solid Oral Dosage Forms

Granulates are commonly used in the production of tablets and capsules, where uniform dosing, good flow and consistent compression behavior are essential. Pharmaceutical granulation processes include wet granulation, dry granulation and melt granulation, selected according to formulation requirements and API stability. Key quality attributes include granule size distribution, density, porosity and residual moisture content.

By transforming fine, dust-forming powders into free-flowing granulates, pharmaceutical manufacturers achieve improved process stability and reproducibility. Granules represent a critical intermediate step that enables efficient scale-up from development to commercial production of solid oral dosage forms while supporting compliance with regulatory quality standards.

Ready to produce the perfect granules?

Discover our fluid bed and high-shear granulation systems or learn more about granulation: